代表作 1. Yangtao Wu1, X. Huang1, L. Yuan1, S. Wang1, Y. Zhang1, H. Xiong1, R. Chen, J. Ma, R. Qi, M. Nie, J. Xu, Z. Zhang, L. Chen, M. Wei, M. Zhou, M. Cai, Y. Shi, L. Zhang, H. Yu, J. Hong, Z. Wang, Y. Hong, M. Yue, Z. Li, D. Chen, Q. Zheng, S. Li, Y. Chen, T. Cheng, J. Zhang, T. Zhang, H. Zhu, Q. Zhao, Q. Yuan, Y. Guan, N. Xia, A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters. Sci Transl Med. 2021 Aug 11;13(606):eabg1143. https://doi: 10.1126/scitranslmed.abg1143. 2. X. Huang, X. Wang, J. Zhang, N. Xia, Q. Zhao, Escherichia coli-derived virus-like particles in vaccine development, Npj Vaccines. 2 (2017). https://doi.org/10.1038/s41541-017-0006-8. 3. X. Huang1, Y. Li1, M. Nie, M. Yue, Y. Li, Z. Lin, H. Pan, M. Fang, T. Wu, S. Li, J. Zhang, N. Xia, Q. Zhao, Capsid destabilization and epitope alterations of human papillomavirus 18 in the presence of thimerosal, J. Pharm. Anal. (2020). https://doi.org/10.1016/j.jpha.2020.08.007. 4. S. Chen1, X. Huang1, Y. Li, X. Wang, H. Pan, Z. Lin, Q. Zheng, S. Li, J. Zhang, N. Xia, Q. Zhao, Altered antigenicity and immunogenicity of human papillomavirus virus-like particles in the presence of thimerosal, Eur. J. Pharm. Biopharm. 141 (2019) 221–231. https://doi.org/10.1016/j.ejpb.2019.05.027. 5. C. Zhang1, X. Huang1, S. Chen, Y. Li, Y. Li, X. Wang, J. Tang, L. Xia, Z. Lin, W. Luo, T. Li, S. Li, J. Zhang, N. Xia, Q. Zhao, Epitope clustering analysis for vaccine-induced human antibodies in relationship to a panel of murine monoclonal antibodies against HPV16 viral capsid, Vaccine. 36 (2018) 6761–6771. https://doi.org/10.1016/j.vaccine.2018.09.035. 6. Y. Li, X. Huang, Z. Zhang, S. Li, J. Zhang, N. Xia, Q. Zhao, Prophylactic hepatitis E vaccines: Antigenic analysis and serological evaluation, Viruses. 12 (2020). https://doi.org/10.3390/v12010109. 7. Y. Lin, X. Wang, X. Huang, J. Zhang, N. Xia, Q. Zhao, Calcium phosphate nanoparticles as a new generation vaccine adjuvant, Expert Rev. Vaccines. 16 (2017) 895–906. https://doi.org/10.1080/14760584.2017.1355733. 8. Wang X, Yin X, Zhang B, Liu C, Lin Y, Huang X, Li Y, Shen C, Zheng W, Fu G, Chen J, Wen Y, Zhang W, Pan BS, Fang M, Zheng Z, Zhang Z, Yuan Q, Fu G, Li S, Zhang J, Chen Y, Xia N, Zhao Q. A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity. Emerg Microbes Infect. 2022 Dec;11(1):914-925. https://doi.org/10.1080/22221751.2022.2050951. 9. L. Xia, Y. Xian, D. Wang, Y. Chen, X. Huang, X. Bi, H. Yu, Z. Fu, X. Liu, S. Li, Z. An, W. Luo, Q. Zhao, N. Xia, A human monoclonal antibody against HPV16 recognizes an immunodominant and neutralizing epitope partially overlapping with that of H16.V5, Sci. Rep. 6 (2016).
https://doi.org/10.1038/srep19042. 10. T.Y. Zhang, X.R. Guo, Y.T. Wu, X.Z. Kang, Q.B. Zheng, R.Y. Qi, B.B. Chen, Y. Lan, M. Wei, S.J. Wang, H.L. Xiong, J.L. Cao, B.H. Zhang, X.Y. Qiao, X.F. Huang, Y. Bin Wang, M.J. Fang, Y.L. Zhang, T. Cheng, Y.X. Chen, Q.J. Zhao, S.W. Li, S.X. Ge, P.J. Chen, J. Zhang, Q. Yuan, N.S. Xia, A unique B cell epitope-based particulate vaccine shows effective suppression of hepatitis B surface antigen in mice, Gut. 69 (2020) 343–354. https://doi.org/10.1136/gutjnl-2018-317725. 11. Z. Zhang, T. Zhang, L. Cao, X. Wang, J. Cao, X. Huang, Y. Cai, Z. Lin, H. Pan, Q. Yuan, M. Fang, S. Li, J. Zhang, N. Xia, Q. Zhao, Simultaneous in situ visualization and quantitation of dual antigens adsorbed on adjuvants using high content analysis, Nanomedicine. 14 (2019) 2535–2548. https://doi.org/10.2217/nnm-2019-0016. 12. T. Li1, Q. Zheng1, H. Yu1, D. Wu1, W. Xue1, H. Xiong1, X. Huang, M. Nie, M. Yue, R. Rong, S. Zhang, Y. Zhang, Y. Wu, S. Wang, Z. Zha, T. Chen, T. Deng, Y. Wang, T. Zhang, Y. Chen, Q. Yuan, Q. Zhao, J. Zhang, Y. Gu, S. Li, N. Xia, SARS-CoV-2 spike produced in insect cells elicits high neutralization titres in non-human primates, Emerg. Microbes Infect. 9 (2020) 2076–2090. https://doi.org/10.1080/22221751.2020.1821583. |